Home|Journals|Articles by Year

Directory for Medical Articles
 

Original Article

pnr. 2021; 12(2): 44-48


Spectrophotometric Determination of Metoclopramide- HCl in the standard raw and it compared with pharmaceuticals

Safaa H. Ganduh, Aseel M Aljeboree, Makarim A. Mahdi, Layth S. Jasim.


Abstract

This research has been based on the development of a fast, simple, sensitive, highly selective and accurate way for spectrophotometric estimation of metoclopramide hydrochloride (MCP HCl) drug in various pharmaceutical preparations. The method spectrophotometric depends on the diazotization of the primary amino group (MCP-HCl) with hydrochloric acid and (NaNO2) solution, also by interaction with a drug considered as a coupling agent is Phenylephrine hydrochloride (PH-HCl) in an alkaline medium. After completing the reaction, the orange color is formed, evidence of forming a stable azo dye for three hours and has a wavelength of 452 nm. Beers' law was applied in the range concentration of 1-10 mg/L, Correlation coefficient (r2=0.9995). Factors affecting absorbance and color stability were studied like Effect of sodium nitrite volume, Study of kind and acid concentration, Effect of Phenylephrine hydrochloride volume reagent: the optimum temperature was 25°C, the reaction time was 5 min., and the volume of Phenylephrine hydrochloride (PH-HCl) reagent was 1ml. The limit of detection (LOD) 1.21 x 10-2, the limit of quantification (LOQ) 4.063x10-2. Recoveries range 96.1%-104.1%. The way has been successfully useful to analyze the compound (MCP-HCl) in its pharmaceutical preparations (tablets, syrup).

Key words: Colorimetric, Spectrophotometric, Determination, Phenylephrine hydrochloride Metoclopramide- HCl.






Full-text options


Share this Article



Online Article Submission
• ejmanager.com







eJManager.com
Review(er)s Central
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.