Home|Journals|Articles by Year|Audio Abstracts

Review Article

Vitamin D Deficiency: A Potential Factor Behind Depression

Archana Nimesh, Aparna Das, Thoraya Mohamed Elhassan A-Elgadir, Rishi Kumar Bharti, Rehan Monir, Ayoub Ali AlShaikh, Sathishbabu Murugaiyan.

Cited by 0 Articles

Depression, a leading cause of disability affecting around 264 million people globally has multifactorial causes like psychosocial, biological, genetic and hormonal. Vitamin D, a neuroactive steroid easily crosses blood brain barrier and has widespread receptors in the brain tissue suggesting that vitamin D could have a role in the brain functioning. This paper reviews if vitamin D deficiency is associated with depression and the possible biochemical mechanisms for explaining the same. For this review, scientific studies published till December 2021 were searched on PubMed, Google Scholar and Google using keywords, vitamin D, vitamin D deficiency, depression, mechanisms, association and supplementation. Studies have found that vitamin D is important for expression of neurotransmitters, neuroimmunomodulation and antioxidant production. Neurotrophic hypothesis and monoamine neurotransmission hypothesis explains the biochemical mechanisms behind depression. Many studies found insufficient vitamin D levels being associated with depression and the symptoms improved upon vitamin D supplementation. Thus, it is recommended that serum vitamin D in depression patients should be monitored and normalized if found deficient. Vitamin D supplementation as an adjuvant therapy to standard antidepressants therapy could be more effective to treat depression not responding to standalone vitamin D supplementation. Vitamin D may be used to treat depression especially in patients with poor compliance to antidepressant drugs.

Key words: vitamin D, vitamin D deficiency, depression, mechanism, association, vitamin D supplementation

Full-text options

Share this Article

Online Article Submission
• ejmanager.com

ejPort - eJManager.com
Refer & Earn
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under Creative Commons Attribution 4.0 International License (CC BY), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.