Home|Journals|Articles by Year|Audio Abstracts

Review Article

QSAR Study of Some Natural and Synthetic Platelet Aggregation Inhibitors and their Pharmacological Profile

Valery M. Dembitsky, Tatyana A. Gloriozova, Vladimir V. Poroikov, Maju M. Koola.


Several well-known synthetic drugs, such as aspirin, elinogrel, and beraprost, and natural drugs, such as eptifibatide and vorapaxar, as platelet aggregation inhibitors are widely used in clinical medicine today. The purpose of this review is a comparative pharmacological analysis of the biological activity of these drugs with natural sulfur-containing hydrocarbons isolated from bacteria, plants, and mineral oils. According to the quantitative structure–activity relationship estimates, these naturally occurring sulfur-containing hydrocarbons are more likely to exhibit antiplatelet properties than those currently used in clinical medicine.

Key words: Antiplatelet, synthetic, natural, drugs, aspirin, aggregation, platelet, thrombin,

Full-text options

Share this Article

Online Article Submission
• ejmanager.com

ejPort - eJManager.com
Review(er)s Central
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under Creative Commons Attribution 4.0 International License (CC BY), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.