Home|Journals|Articles by Year

Directory for Medical Articles

Research Article

JCDR. 2021; 12(4): 1177-1185


Radhika Penmetsa, kranthi kumar pola, Y. Rajendra, B. Durga Prasad, A. Srinivas Rao, Mohd Afroz.


The present report was aimed at solid state manipulation of nabumetone. Nabumetone is a nonsteroidal anti inflammatory agent with slightly low risk of GI side effects. Different crystal forms of nabumetone were prepared using solvents of different polarity by four techniques, namely solvent evaporation, heating, quench-cooling and seeding. Microscopy, FTIR, X-ray diffractometry (XRD), and differential scanning calorimetry (DSC), were used to characterize crystalline forms of the nabumetone. Acicular and rod shaped crystals were obtained. Metastable polymorphs of nabumetone were identified on the basis of low melting points, and converted into stable form as indicated by the high melting point over a period of 2 months. The polymorph was identified as Form II was reported by earlier works. Evidence indicated that there are two different crystal habit of nabumetone. Physicochemical properties such as melting point, solubility and dissolution were evaluated. Crystals obtained from isopropyl alcohol, and isobutyl alcohol had nearly two fold higher aqueous solubility. Crystals obtained from ethanol has gradual and increased dissolution rate. These crystals may have still low risk of GI side effects.

Key words: Nabumetone, Glipizide, Solubility, Ethanol, Dissolution, Crystals.

Full-text options

Share this Article

Online Article Submission
• ejmanager.com
• ojshosting.net

Do you want to use OJS for your journal ?
work with an experienced partner

Review(er)s Central
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.