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Research Article

. 2021; 12(4): 984-995


DEVELOPMENT AND EVALUATION OF EUDRAGIT FLOATING MICROSPHERES CONTAINING EZETIMIBE

Josephine Leno Jenita*, Seema S. Rathore,Konduru Rohini, Manjula D, Shanaz Banu, Mahesh AR, Wilson Barnabas.

Abstract
The purpose of this research work was to formulate and evaluate the floating microspheres of poorly water-soluble drug, ezetimibe by emulsion solvent diffusion evaporation technique using eudragit RS 100 and eudragit RL 100. The formulated microspheres were characterized for various parameters. The microspheres with Eudragit RS 100 showed drug loading of 20.9 to 81.8% and the particle size of 2.631 to 7.254 Ámand the microspheres with Eudragit RL 100 showed drug loading of 63.5 to 73.6%, the particle size distribution of 1.549 to 5.962 Ám. The prepared microspheres were white, free-flowing and virtually spherical in shape.The drug release was extended up to 10 h and its release mechanism from formulations followed the super case-II transport which indicated that drug release from floating microspheres by diffusion controlled polymeric relaxation

Key words: Ezetimibe; Eudragit RS100;Eudragit RL100; Floating microspheres; Anti-hyperlipidemic






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The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.