The study was aimed to investigate the hypolipidemic potential of methanolic extract
Tecomastansleaves in high cholesterol-fed rats. The preliminary study showed thatT.stans leaves
were able to scavenge the 2,2-azino-bis (3-ethylbenzthiazoline-6-sufonic acid) (ABTS) and 2-
Diphenyl-1- picrylhydrazyl (DPPH) radicals and these radicals scavenging abilities were found
to be dose-dependent. Administration of cholesterol to rats for 45 days induced a significant
increase in the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST),
alkaline phosphatase (ALP), and increase lipids levels in the plasma and tissues while HDL
cholesterol was decreased. It also elevated the levels of malondialdehyde (MDA) and decreased
superoxide dismutase (SOD) activities in the tissues. However, co-administration of high
cholesterol-fed rats with T.stans extract at doses of 100 and 200 mg/kg significantly reversed
lipids levels to near normal with cholesterol in the plasma, liver, heart, kidney and lung reduced
by (23.13% and 56.43%), (30.09% and 20.90%), (38.21% and 74.53%), (12.61% and 32.49%)
and (37.11% and 29.90%) respectively while HDL cholesterol level was increased by (225.44%
and 110.39%). The levels of AST, ALT and ALP in the plasma and MDA in the tissues were
also decreased while SOD activities in the liver, heart, kidney and lung were elevated by
(89.35% and 149.21%), (74.91% and 68.35%), (56.76% and 114.77%), and (204.91% and
274.62%) respectively. The extractofT.stans was found to be rich in phenolic content and was
proved to have no toxic effects on rats when administered alone to normal rats at a dose level of
200mg/kg/day. The results obtained in this study demonstrated the antioxidant and lipidlowering
effects of T.stansand, suggests that the plant could serve as a new potential natural
product for the treatment of hyperlipidemia.
Key words: Tecomastans ,scavenge,malondialdehyde, high cholesterol, hyperlipidemia
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