Home|Journals|Articles by Year|Audio Abstracts
 

Research Article

IJPRT. 2023; 13(2): 52-64


Design And Evaluation of Topical Gel Containing Solid-Lipid Nanoparticles Loaded with Luliconazole

JHANSI YALLAVULA, KIRANMAI MANDAVA, VENU MADHAV.




Abstract

New topical pharmaceutical options are critically needed to obviate fungal infections. Luliconazole is a potent antifungal drug for the treatment of fungal infection. Due to bioavailability barriers of luliconazole, the current study is associated to develop an optimized topical luliconazole solid lipid nanoparticles (SLN) gel formulation against tropical fungal infection with prolonged therapeutic potential. Luliconazole loaded SLN were prepared
through the solvent diffusion method using stearic acid & poloxamer 188 and optimized as per their entrapment efficacy. Thereafter, the optimized SLN wes subjected to physicochemical evaluation, followed by the preparation of different gel formulation. The physicochemical parameters of the optimized gel formulation (G3) were evaluated. Further anti-fungal activity of the G3 was determined against the growth of Candida albicans by TLC-Bioautography assay. The results reveal that SLN F6 shows a significant entrapment with 92.13%±0.975 entrapment efficacy. In particle size, size distribution and zeta potential analysis, SLN exhibit a mean particle diameter of ~344.3 nm, PDI of 0.168, intercept value 0.98 and zeta potential ~18.8 mV. The G3 shows a higher entrapment with 91.39%±0.187 entrapment efficacy and in-vitro drug release profile of the G3 with 1.5 % carbopol 934 w/v shown a sustained release profile with 79.57%±0.213 desolvation rate even after 24 hrs. The anti-fungal activity of SLN G3 gel showed a strong zone of inhibition of the growth of C. albicans. Hence, the study concludes that luliconazole loaded SLN G3 gel formulation containing 1.5% w/v carbopol 934 is suitable for topical application and having strong anti-fungal activity.

Key words: Solid lipid nanoparticles, Luliconazole, Tropical gel formulation, Anti-fungal activity






Full-text options


Share this Article


Online Article Submission
• ejmanager.com




ejPort - eJManager.com
Refer & Earn
JournalList
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under Creative Commons Attribution 4.0 International License (CC BY), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.