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Research Article

SRP. 2020; 11(8): 439-445


Influence of Regular Feasible Physical Activity on the Platelet’s Functional Activity of the Second Mature Age People

Karpov Vladimir Yurevich, Zavalishina Svetlana Yuryevna, Dorontsev Alexander Viktorovich, Voronova Natalia Nikolaevna, Shulgin Alexander Mikhailovich, Sharagin Victor Ivanovich, Koz'yakov Roman Valerievich.




Abstract

It is known that feasible regular muscle training of an aerobic nature helps to reduce platelet activity of people with high normal blood pressure. At the same time, the physiological reaction of platelets to regular physical activity of the second mature age people with already formed arterial hypertension remains not entirely clear. Purpose of the study is to find out the possibilities of regular moderate aerobic physical activity of the second mature age people with newly developed arterial hypertension. The platelets functional activity of physically exercising and avoiding physical exercises people of the second mature age with arterial hypertension was traced by using optical aggregatometry and cytometry with an assessment of P-selectin level and GP IIb-IIIa on the platelet surface. The platelet aggregation activity and the number of GP IIb-IIIa molecules and P-selectin on platelet membranes of patients who took aspirin and had low physical activity and under the control were comparatively high. Platelet aggregation of patients, who trained physically, was not expressed, and under the ADP action on platelet membranes, the amount of GP IIb-IIIa and P-selectin did not change significantly. The paper shows the possibility of weakening the platelets activity of patients with recent arterial hypertension under the influence of regular physical activity. The results obtained give a reason to consider regular dosed physical activity as an obligatory component of the treatment of this category of patients to minimize the development of their thrombotic manifestations.

Key words: Arterial hypertension, P-selectin, GP IIb-IIIa, Aggregation, Platelets, ADP, physical exercise.






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