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Review Article

SRP. 2020; 11(9): 43-51


IN-VITRO EVALUATION OF THE ANTICANCER ACTIVITY OF Cu(II)AMINA(CYSTEINE)DITHIOCARBAMATE

Desy Kartina, Abdul Wahid Wahab, Ahyar Ahmad, Rizal Irfandi, Prihantono, And Indah Raya.


Abstract

The Complex of Cu(II)cysteinedithiocarbamate has been synthesized, it was prepared by the “in situ method” and characterized by using Ultraviolet-Visible (UV-Vis), Infra-Red (IR) spectroscopy, X-Ray Fluorescence (XRF) instruments. While melting point and conductivity also measured. The presence of UV-Vis maximum spectrums of Cu(II)cysteinedithiocarbamate at 296 nm and 436 nm indicated that electronic transition π→π* dan n→π* of CS2 and N=C=S myotis. The presence of the wavelength in the region of 399-540 cm-1 of IR spectra is indicated that has been coordination occurred between Cu(II) with Sulphur (S), Nitrogen (N), and Oxygen(O) atoms respectively from cysteinedithiocarbamate ligands. The XRF data confirm the presence of Cu and S in the new compound formed. The XRD spectrums also showed several hkl of CuO, CuS, and CuN indicating there is an interaction between Cu(II) with N, S, and O atoms. Cytotoxic test of Cu(II)cysteinedithiocarbamate complex has IC50= 639,35 µg/mL which indicates that the complex can induce the morphological MCF-7 cancer cells changes towards apoptosis.

Key words: Anticancer, Cu(ll)Amina(cysteine)dithiocarbamate.






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