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Review Article

SRP. 2020; 11(5): 850-861


To Consider The Organogel Of Span 40 And Span 60 In Sesame Oil As A New Member In The Gastro Retentive Drug Delivery Systems

Zainab Saad Kaddoori, Masar Basim Mohsin Mohamed, Wesam R. Kadhum, Nawfal Am. Numan.


Abstract

To explore the ability of organogel for floating in acidic media to obtain a novel member gastroretentive dosage form testing span 40 and span 60 as a gelators, sesame oil (SO) as an apolar phase and cinnarizine (CN) as a model drug to produce an organogel as a gastroretentive drug delivery system. Floating properties were studied like floating lag time and floating duration for the organogels in both solid and liquid status. Characterizations of organogels were studied by assessment of thermal behavior by tabletop rheology and probing the organogels morphology with an optical microscope, the assembly of gelators was investigated by Fourier-transform infrared spectroscopy (FTIR). Oscillatory rheology studies, the amplitude sweep and frequency sweep were conducted. These were followed by in- vitro release and in-vivo floating studies. The results showed that all span organogels floated instantly and for around 24 hours in both statuses. Also, all span organogels showed reversible transition temperature and higher than 37 ºC and the optical images showed fibrillar scaffold where the fibers length of span 40 organogel were significantly shortening with increasing concentration of span 40 and the non significant change was with span 60.The hydrogen bonds were responsible on gelator-gelator interactions by a shift in the peaks that associated with the carbonyl and hydroxyl groups. Moreover, organogels showed the viscoelastic properties as the 20% w/w of span 40 and span 60 organogels were frequency independent. Last, organogels slowed the release of CN and persisted in rat’s stomach for 12 hours.

Key words: span 40- span 60- low molecular weight organogelator- organogel- floating system-gastroretentive drug delivery system.






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