There is a lack of reliable hepatoprotective drugs in modern medicine to prevent and treat drug-induced liver damage. Fruits of Plum (P. domestica), belonging to family Rosaceae are used traditionally for their hepatoprotective effect. We wanted to evaluate the hepatoprotective activity of Prunus domestica synergistic hepatoprotection exists with silymarin.
Materials and Methods:
Albino rats (150–200 g) were divided into seven groups. Groups 1 and 2 were normal and experiental controls, respectively. Groups 3, 4, 5, 6 received the ethanol, methanol, chloroformand petroleum ether extract of P. domestica fruits 100 mg/kg BW/day, and Group 7 positive control silymarin (25 mg/kg, p.o.) respectively, for 10 days. Hepatotoxicity was induced in all on the eighth day with paracetamol 2 g/kg BW/day. The hepatoprotective effect was evaluated by performing an assay of the serum proteins, Serum bilirubin, SGPT, SGOT and ALP. The assay results were presented as mean and standard error of mean (SEM) for each group. The study group was compared with the control group by one-way ANOVA, followed by Dunnett's Multiple Comparison Test. A P-value of
Hepatoprotective, hepatotoxicity, P. domestica, paracetamol, silymarin
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