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Research Article

JCR. 2020; 7(18): 3057-3070


Anuj Chauhan, Manoj Kumar Sagar, Sachin Kumar, Atul Sharma.

For decades oral medical devices have been known as the most widely-used route of administration across all routes for the systemic distribution of medicinal products by different drug products of various dosage types, comprising between 50%-60% of the total formulations of drugs. The most favored direction is now this pattern. Due to its manifold advantage from extended-release (in certain cases) and patient behavior, including the ease of ingestion, most importantly.
The reason for such popularity can be partially the easy administration of the drug as well as the traditional conviction that it is well absorbed through oral administration as food that is taken regularly. Regardless of the physical form of the pharmaceutical product for oral delivery, the optimization of dosage forms characteristics within the inherited constraint of GI physiology differs.
Carrier technology provides an intelligent drug delivery approach by connecting the drug to carrier particles such as microspheres, nanoparticles, liposome, etc. that modulates the release and absorption properties of the drug. Because of their small size and efficient carrier characteristics, microspheres are an important part of these particulate DDS.
However, because of their short residence time at the absorption site, the success of these new DDS is limited. Therefore, it would be beneficial for the absorbent membranes to be intimately in contact with the DDS. The bio-adhesion characteristics can be linked to microsphere and novel delivery mechanisms can be built such as bioadhesivemicrospheres
The present work was aimed at preparing floating Metformin hydrochloride microspheres. Metformin hydrochloride has been developed to prolong the duration of gastric residency and to increase drug bioavailability with reduced GI side effects in a multi-unit floating oral dosage form. The floating microsphere was created by an inotropic gelation method that was used to diffuse metformin hydrochloride in a separate mixture of anionic sodium alginate and carbopol 934 as a primary polymer comprising an opposite-loaded counter-ion polymer called HPMC K4M. Micromeritics characteristics, percentage yield, loading medications, drug trapping, particular shape and size studies, and in-vitro drug release experiments were evaluated for the prepared microspheres.

Key words: Metformin hydrochloride, HPMC K4M, Bioadhesive microsphere.

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