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Research Article

. 2021; 12(6): 191-196

Assessment Of Ankle Brachial Index and Osteopontin In Type 2 Diabetic Individuals With Lower Extremity Arterial Disease

Jehan Saeed, Sally Mahmoud Saeed, Ali Irhoumah Mohamed, Mohamed Gaber Hamed.

Background:Lower extremity arterial disease (LEAD) is a major endemic disease with an
alarming increased prevalence worldwide and it is a major manifestation of systemic
atherosclerosis with severe associated cardiovascular, lower limb and functional
complications.The anklebrachial index (ABI) is a simple, non-invasive, widely used test that
detects lower extremity arterial disease.Osteopontin (OPN) is a multifunctional protein
independently discovered by investigators from diverse scientific backgrounds and
implicated in a broad array of pathological process.
Objective: This study aimed toinvestigate the differencesin ABI measurementsand serum
OPN levels between type 2 diabetic (T2D) subjects with and without LEAD.
Patients and Methods: This case control study was conducted at the Internal Medicine,
Endocrinology Unit and Biochemistry Departments of Zagazig University Hospitals. 30
participants were classified into two groups. Group 1(n =30) healthy subjects (control),
Group 2 (n =30) T2D diabetic subjects, who were further subdivided into two groups: 2A
(n=15) T2D subjects with LEAD and 2B T2D subjects without LEAD. Measurement of
Ankle brachial index madeby handheld doppler.Serum osteopontin levels were performed by
ELISA kits.
Results:Ankle brachial index measurements were significantly lower among diabetic with
LEAD group compared to diabetic without LEAD group (p=0.000) and osteopontin values
was higher in diabetic with LEAD than diabetic without LEAD group with highly significant
results (p=0.000).
Conclusion: The study concluded thatABI measurements and serum OPN levels have
important value in detection of lower extremity arterial disease in subjects with type 2
diabetes mellitus.

Key words: Ankle brachial index, Lower extremity arterial disease, Type 2 D Mellitus

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The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.