JCR. 2020; 7(17): 2994-3004
ANTI-PARKINSON'S ACTIVITY OF EMBLICA OFFICINALIS AND TERMINALIA BELLIRICAHimani Badoni, Promila Sharma, Manoj K. Pal, Kumud Pant, Bhawana, Neetu Sharma, Nilay Singh, Syed Mohsin Waheed, Prof Dr. Bindu Agarwal.
In the present study, methanolic extracts of fruits of Emblica officinalis (EOM) and Terminalia
bellirica (TBM) were screened for their anti-Parkinson's activity. Haloperidol (1 mg kg-1) was given to male
Wistar rats to induce catalepsy and Parkinsonís disease-like symptoms. Effect of EOM and TBM (300 mg kg-1,
p.o.) pretreatment was observed on behavioural parameter like catalepsy and biochemical parameters like lipid
peroxidation (LPO), glutathione (GSH), catalase (CAT) and superoxide dismutase (SOD). The increased
cataleptic score induced by haloperidol was found to be significantly reduced with the EOM and TBM
pretreatment given orally for five days each at a dose of 300 mg kg-1. Haloperidol treatment showed significant
increase in lipid peroxidation level and depleted superoxide dismutase, catalase, and glutathione levels, whereas
daily administration of EOM and TBM (300 mg kg-1, p.o.) significantly attenuated lipid peroxidation level and
enhanced superoxide dismutase, catalase, and glutathione levels. Thus, the study demonstrates that EOM and
TBM treatments significantly attenuate the symptoms of catalepsy and protects the brain from oxidative stress
by modulation of oxidative stress markersí profile.
Parkinsonís disease, haloperidol, catalepsy, oxidative stress