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Research Article

JCDR. 2021; 12(3): 2379-2387


ASSOCIATION BETWEEN EOSINOPHIL LEVEL AND PREDICTION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE EXACERBATION

Ahmed Rabeih Mohammed, Mostafa I. Ragab, Ali Nagat Mohammed, Maha E. Alsadik.


Abstract

Background:Chronic obstructive pulmonary disease (COPD) is a common treatable and preventable diseasecharacterized by progressive airflow limitation with an enhanced chronic inflammatory response in the airways.Acute exacerbation of COPD is associated with substantial morbidity and mortality.This study aimed to predict the outcome and future risk of COPD exacerbations and to improve the health quality of COPD patients.Patients and methods: A Cohort prospective study was designed to investigate thirty four hospitalized COPD patients with COPD exacerbation whether in the ward or in the ICU and follow up them for 12 months.Results:Outcome of the exacerbation at admission among the studied patients; 32.4% of had sputum eosinophilia and most of them (76.5%) received LABA as treatment before admission. There was no statistically significant association between eosinophils level at admission and the outcome among the studied group where one patient (9.1%) died among patients with eosinophilia‚Č•2% and also one patient (4.3%) died among patients with eosinophils1.25%), half of them (50.0%) had future single exacerbation, about one third (34.4%) had two exacerbations and (15.6%) had no further exacerbations. all of them (100.0%)received LABA, LAMA and ICS as a triple therapy. There was statistically significant higher TLC, neutrophil count and longer hospital stay among patients with eosinophils

Key words: COPD;Eosinophils; Neutrophil;CAT Score; Exacerbations






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