Improvements in science and technology have contributed immensely to every aspect of dental care. Regenerative endodontics (RE) aims to restore the vitality of the non-vital pulp; that is why regenerative therapy is considered as the future of dentistry. RE is anticipated to restore harmed or missing structures, including root, dentin, pulp-dentin complex, and living tissues identical to the exact origin that replaces the normal physiological functions of the pulp-dentin complex. The current review aimed to educate and update young general practitioners about RE by an overarching review of the available literature and give them a clear picture of the state of knowledge on the subject. An electronic search on PubMed and Google Scholar was undertaken to review articles on regenerative procedures and revascularization using specific keywords, such as "regenerative endodontics," "revascularization," "immature permanent teeth," "stem cells," "case report," "growth factors," and "scaffold," to collect enough information and recommendations regarding the indications, medications, and methods of treatment currently practiced. This review article screened about 100 papers published from 1971 to 2020 in appropriate peer-reviewed journals. These articles were initially filtered based on the title and abstract. All the pieces were inspected thoroughly and then chosen as per the inclusion criteria. For additional information, relevant literature for RE in textbooks was also reviewed. Regenerative dental techniques are emerging as a worthy, advanced dentistry field, creating a paradigm shift in many dental specialties, including endodontics. Conventional endodontic therapy aims to preserve or restore the health of periarticular tissues by preventing or healing apical periodontitis. However, the goals of regenerative procedure extend beyond the purposes of conventional endodontic therapy and include continued root development and reestablishment of pulpal vitality.
Key words: Regenerative, immature permanent teeth, apexification, case report