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Anti-proliferative activities of Solasodine extracts from different Solanum spp. Cell cultures on Colon and Bone carcinoma cell lines

Vijaykumar Deshmukh, Sangeeta Ballav, Soumya Basu, Sanjay Mishra, Jyoti Deshpande, Minal Wani.


Abstract

Solasodine is a steroid glycoalkaloid (aglycone) found in the genus Solanum (family Solanaceae). Solanum is widely used as a traditional medicinal herb, and solasodine is documented for various pharmacological properties like antioxidant, hepatoprotective, neuroprotective, and anticancer activities. In the present study, the cytotoxic effects of solasodine extracts of in vitro cultured four Solanum species, namely, S. surattense, S. villosum, S. nigrum, and S. incanum has been assessed on two cancer lines, including Human Colorectal Adenocarcinoma cell line (HT-29), Osteosarcoma cell line (MG-63), and also on normal (Normal fibroblast L-929) cell lines in vitro. Results revealed significant cytotoxic effect on both HT-29 and MG-63 cancer cell lines, whereas very less cytotoxicity for the normal cells which indicate the major targeting of extracted solasodine on cancer cells only. Moreover, S. surattense extract found to have greater cytotoxic effect on HT-29 cells and S. nigrum extract on MG-63 cells. The results exhibited an active anti-proliferative role of solasodine extracts on colon and bone cancer cell lines which suggests the usage of these extracts as novel targeted therapy in colon and bone cancers.

Key words: Cytotoxicity, anticancer activity, Solasodine, Solanumextracts






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