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Original Article

pnr. 2011; 2(2): 91-98

A comparative study of pheniramine and lorazepam for physiological and cognitive/psychomotor task impairment

Yatan Pal Singh Balhara, Raka Jain, Anju Dhawan, Manju Mehta.


Context: Pheniramine is being used harmfully in combination with opiates and benzodiazepines through injecting route. Aims: The present study is an attempt to compare the physiological and psychomotor/cognitive task performance on pheniramine and lorazepam. Settings and Design: The study used a double blind randomly allotted cross-over design. Materials and Methods: The doses of the drugs used were placebo (normal saline) - 2 ml, Pheniramine maleate - 45.5 mg, Lorazepam - 2 mg. The assessments were made at base line and then at 15 min., 120 min and 240 min. The subjects were assessed for the socio-demographic profile, drug use history, physiological parameters (pulse rate, BP, respiratory rate), and psychomotor/cognitive tasks. Statistical Analysis used : Analysis was carried out using SPSS ver 10.0. In between, drug comparisons were done using one-way ANOVA (multiple comparisons). Results: Physiological and cognitive/psychomotor tasks performance did not show any significant difference between pheniramine, lorazepam and placebo. Conclusions: The findings suggest the pheniramine and lorazepam have comparable impairment on physiological and cognitive/psychomotor task performance.

Key words: Lorazepam, pheniramine, psychomotor functions

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