Home|Journals|Articles by Year Follow on Twitter

Directory for Medical Articles

Open Access

Original Article

pnr. 2011; 2(2): 58-61

Hydroethanolic leaf extract of Ficus religiosa lacks anticonvulsant activity in acute electro and chemo convulsion mice models

Damanpreet Singh, Bikram Singh, Rajesh Kumar Goel.

Introduction: Ficus religiosa L. (Moraceae) has been of great medicinal value in traditional medicine and implicated in a wide variety of human and animal disorders. Its leaves have been used for the ethnomedical treatment of epilepsy. But its traditional antiepileptic use is not fully understood experimentally. Hence the present study was undertaken to explore the anticonvulsant effect of the leaves in experimental animal models of convulsion. Materials and Methods: The anticonvulsant effect of hydroethanolic leaf extract of F. religiosa was studied at 100, 250 and 500 mg/kg; intraperitoneally (i.p.) in maximal electroshock (MES), and at 100, 250, 500 and 600 mg/kg; i.p. doses in pentylenetetrazol (PTZ) test in mice. The duration of tonic hind limb extension(s) and latency to clonic convulsions (min) was noted in MES and PTZ tests, respectively. Phenytoin (25 mg/kg; i.p.) and diazepam (5 mg/kg; i.p.) served as reference standards in MES and PTZ tests, respectively. Percentage mortality was also noted. Results: There was no significant change observed after the extract treatment on the duration of tonic hind limb extension in MES test, and latency to clonic convulsions in PTZ test, as compared to their respective controls. Moreover, percentage mortality remained unaltered after the extract treatment. Conclusions: From the results of present study it is concluded that the hydroethanolic leaf extract of F. religiosa lacks anticonvulsant activity in MES- and PTZ-induced convulsion tests. Further studies are required from other regions and using different animal models to support these findings.

Key words: Convulsions, epilepsy, Ficus religiosa L., maximal electroshock, pentylenetetrazol, traditional medicine

Similar Articles

Differentiating Human Pluripotent Stem Cells to Vascular Endothelial Cells for Regenerative Medicine, Tissue Engineering, and Disease Modeling.
Bertucci T, Kakarla S, Kim D, Dai G
Methods in molecular biology (Clifton, N.J.). 2022; 2375(): 1-12

Microgel assembly: Fabrication, characteristics and application in tissue engineering and regenerative medicine.
Feng Q, Li D, Li Q, Cao X, Dong H
Bioactive materials. 2022; 9(): 105-119

Method for Isolating Extracellular Vesicles from Human Neural Stem Cells Expanded Under Neurosphere Culture.
Koopaei NN, Schmittgen TD, Reynolds BA, Azari H
Methods in molecular biology (Clifton, N.J.). 2022; 2389(): 87-94

Health technology assessment and economic evaluation: Is it applicable for the traditional medicine?
Chen Y
Integrative medicine research. 2022; 11(1): 100756

Exploring the potential application of dental pulp stem cells in neuroregenerative medicine.
Sultan N, Scheven BA
Neural regeneration research. 2022; 17(4): 775-776

Full-text options

Latest Statistics about COVID-19
• pubstat.org

Add your Article(s) to Indexes
• citeindex.org

Covid-19 Trends and Statistics
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.

ScopeMed Web Sites