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Original Article

pnr. 2018; 9(1): 39-43


Triazole-chalcones: Lack of antibacterial, anti-candida, and anti-dengue virus activities

Michelli dos Santos, Felipe Rocha Da Silva Santos, Ariane Coelho Ferraz, Jéssica Tauany Andrade, Karina Marjorie Silva Herrera, William Gustavo Lima, Lailah Horácio Sales Pereira, Marina Goulart da Silva, José Augusto Ferreira Perez Villar, José Carlos de Magalhães, Alex Gutterres Taranto, Luciana Lara dos Santos, Jamária Adriana Pinheiro Soares-Martins, Jaqueline Maria Siqueira Ferreira.


Abstract

Background: The need to identify new antimicrobial drugs that present different mechanisms of action is urgent. The variety of biological properties of chalcones give them a potential therapeutic compounds. Chalcones' synthetic manipulations are investigated worldwide in search of more powerful and efficient drugs to several infectious diseases' treatment. Objective: The purpose of this work was to evaluate the potential antibacterial, antifungal, and anti-dengue virus (DENV) of new ten triazole chalcones. Materials and Methods: Triazole chalcones were used to determine its antibacterial activity against Gram-positive bacteria (Staphylococcus aureus and Staphylococcus epidermidis), Gram-negative bacteria (Klebsiella pneumoniae, Enterobacter cloacae, Acinetobacter baumannii, and Pseudomonas aeruginosa) species, and anti-Candida activity (Candida albicans) by the broth microdilution assay. The anti-DENV activity was evaluated by cell viability quantification after viral infection by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide colorimetric assay. Results: Although Triazole chalcones have shown a low cytotoxicity concentration (with CC50of 47.21–192.51 μg/mL), these compounds did not exhibit antimicrobial activity against Gram-negative and Gram-positive bacteria, C. albicans neither DENV, even in the highest concentration tested. Triazole chalcones had no activity against all tested microorganisms, except for Gram-positive S. epidermidis bacteria when a poor antimicrobial effect was observed (125 μg/mL). Conclusion: The results suggest that triazole chalcones investigated in this study are not promising antimicrobial agents.

Key words: Antibacterial, antifungal, antiviral, chalcones, cytotoxicity






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