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Original Article

pnr. 2018; 9(1): 21-26


Evaluation of the activity of Tontelea micrantha extracts against bacteria, Candida and Mayaro virus

Waleska Stephanie Cruz, Ariane Coelho Ferraz, William Gustavo Lima, Thaís Fátima Silva Moraes, Fernanda Lopes Ferreira, Jaqueline Maria Siqueira Ferreira, Cintia Lopes De Brito Magalhães, Lucienir Pains Duarte, Sidney Augusto Vieira Filho, José Carlos De Magalhães.


Abstract

Objectives: This work aimed to evaluate the antibacterial, antifungal, and anti-Mayaro virus(MAYV) activity of leaf and branch extracts from Tontelea micrantha. Materials and Methods: T. micrantha extracts were prepared through the partition of the leaf and branch samples in different solvents. Then, the antibacterial and antifungal activity was assessed against bacterial pathogens and Candida sp. by the determination of the minimum inhibitory concentration (MIC) by the broth microdilution method. The activity against anti-MAYV was evaluated through the quantification of the extract concentration that promoted the protection of 50% of the cells after the viral infection. Results: The extracts of T. micrantha were inactive (MIC >500 μg/mL) against Gram-positive, Gram-negative and Candida species at the highest concentration tested (500 μg/mL). Anti-MAYV activity was also not detected, with SI

Key words: Antimicrobial activity, branch extracts, leaf extracts






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