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Research Article

ECB. 2022; 11(10): 126-136


Liza Pratiwi.


Ultraviolet (UV) radiation can damage telomeres and induce free radicals, causing cellular senescence. Chronic exposure to UVB rays causes skin aging. An anti-aging drug can be formulated with a delivery system such as SNEDDS. This is an isotropic mixture consisting of oil, surfactant, and co-surfactant which rapidly forms a nanoemulsion when mixed with water. SNEDDS can be a good drug delivery system for protein drugs and drugs with low absorption rates. Topical drug delivery systems have the advantages of bypassing first-pass metabolism, avoiding discomfort risk of intravenous (IV) therapy, improving patientcompliance, and increasing absorption and bioavailability because nanoemulsion-sized droplets can increase the release of poorlysoluble drugs. In delivering drugs and active ingredients into the deep layers of skin, at the dermis, topical route of absorption increases the transport of hydrophobic compounds through the stratum corneum to the deeper layers of the skin and improves the skin availability. This article presents an overview of SNEDDS including its components, formulation design, characterization, potential effects for anti- aging drugs, and penetration as a topical route of delivery.

Key words: SNEDDS, cosmetics, anti-aging, topical

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