Acne is one of the most common skin diseases suffered by humans. Antibiotics are the first line of acne treatment therapy, but the use of antibiotics needs to be reviewed because of cases of resistance. Lakum leaves (Cayaria trifolia L. Domin) is a plant that contains chemical compounds that can be used as alternative therapies, including flavonoids, alkaloids, tannins and saponins that function as antibacterial. The purpose of this study was to determine the role of lakum leaf (Cayratia trifolia L. Domin)as a natural antibacterial for acne therapy. This research is a quantitative study using the true experimental design method, which is measuring the clear zone of lakum leaf extract against Propionibacterium acnes and Staphylococcus epidermidis bacteria found in Nutrient Agar (NA). The antibacterial test method in this study used the well method with variations in the ethanol extract of lakum leaves (Cayratia trifolia L. Domin) with 4 concentrations, namely 25%, 50%, 75% and 100% concentration, acetone as a negative control and clindamycin 30 ppm as positive control. The results showed that the ethanol extract of lakum leaves (Cayratia trifolia L. Domin) contained alkaloids, flavonoids, tannins and saponins. The greatest concentration obtained in inhibiting bacterial growth was at a concentration of 100% extract with an average zone diameter of 20.5 mm for P. acnes bacteria and 21.5 mm for S. epidermidis bacteria.
Key words: Antibacterial, cayratia trifolia, P. acne, S. epidermidis
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