The study aimed to prepare organic compounds that are more resistant to fungi, where antimicrobial resistance occurs when bacteria, viruses, fungi or parasites change their shape over time and do not respond to drugs, which poses a threat to health and development at the global level. New compounds have been prepared from heterocyclic imidazole rings, chalcone, and cyclic-chalcone compounds. Although some new antibiotics are being developed, none of them is expected to be effective in combating the most dangerous forms of antibiotic-resistant bacteria, but these compounds have been studied on several Different types of microbes, some prepared to know their effectiveness in eliminating microbes., Also organic identifications were carried out to supporting results in this study .
Key words: imidazole, cycle, bacteria, microbe, medical, health
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