Background: In this study, we evaluated the oral sub-acute toxicity study of ethanolic roots extract of Coleus
vettiveroides on animal models. Methods:The sub-acute oral toxicity study was carried out as per OECD 423 guidelines. The
study was approved by the Institutional Animal Ethics Committee (IAEC). In sub-acute toxicity study, the oral dose (250, 500
and 1000 mg/kg) of coleus vettiveroides root extract was administered for 28 days to the three animals groups and their body
weight, hematological, serum hepatic biochemical parameters were evaluated and compared to normal group by sacrificing all
group animals. Results: Coleus vettiveroidestreated groups revealed neither mortality nor any significant changes were observed.
The result indicates that the oral administration of ethanolic root extract of Coleus vettiveroides plant did not produce any
significant toxic effect in albino wistar rats. Conclusions: The extract can be utilized safely for therapeutic use in pharmaceutical
formulations.
Key words: Sub acute toxicity, Coleus vettiveroides, hematology, liver.
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