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acute and sub-acute toxicity studies of aqueous leaf extract of launaea taraxacifolia (willd.) in wistar rats

Millicent Ladi Umaru, Kabiru Abubakar, Gabriel Noblefather Uyaiabasi, Giaze Rabiu Tijjani, Yusuf Ibrahim Alkali, Iyabo Mobolawa Adebisi, Oluranti Alebiosu, Soddik Malami Sahabi, Suleiman Abdullahi, Mshelia Emmanuel Halilu.




Abstract

Aim: This study aim to evaluate the acute and sub-acute toxicity profile of aqueous leaf extract of Launaea taraxacifolia (LT) in Wistar rats.

Methods: Acute toxicity was investigated using Lorke’s method, while sub-acute toxicity was assessed using OECD guideline. The first phase of the acute toxicity study had nine Wistar rats randomly divided into three groups (n=3) and administered doses of 10mg/kg, 100mg/kg and 1000mg/kg (po) leaf extract of LT, respectively. In the second phase, four groups animals (n=1) received doses of 1200mg/kg, 1600mg/kg, 2900mg/kg and 5000 mg/kg (po) of the extract, respectively. For the sub-acute toxicity study, twenty rats were randomly divided into four groups (n=5). Group 1 received 10ml/kg distilled water, while Groups 2-4 received 250mg/kg, 500mg/kg and 1000mg/kg (po) of the extract, respectively for 28 days.

Results: Acute toxicity result showed no mortality in both phases of study. In the sub-acute studies, significant increases in platelets in all treatment groups and RBC at the highest dose (1000 mg/kg) of the extract were observed (p

Key words: Ethnopharmacological; Hepatotoxic; Herbal vegetable; Launaea taraxacifolia; Nephrotoxic; Sub-acute toxicity study






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