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Original Article

Open Vet J. 2023; 13(1): 99-107


Effect of ethanol extract from Chrysanthemum cinerariiforium leaves on Ki-67 proliferation and dysplasia severity in a rat model of oral squamous cell carcinoma

Anik Listiyana, Risma Aprinda Kristanti, Al Mazida Fauzil rumondang, Anggun Putri Maulana Ahmad, Lina Fitria Astari, Christyaji Indradmojo, Fidia Rizkiah Inayatilah.




Abstract
Cited by 0 Articles

Background:
Oral Squamous Cell Carcinoma (OSCC) is a malignant tumor that can rapidly infiltrate the oral epithelial tissue and cause high mortality worldwide because the available therapies are less effective. Chrysanthemum cinerariifolium leaf contains secondary metabolites as anti-inflammatory, antioxidant, anticancer, and antimutagenic.
Aims:
The study aimed to analyze the ethanolic extract of C. cinerariifolium leaf in reducing proliferation (Ki-67) and the degree of dysplasia in OSCC rats.
Methods:
This study used male Sprague Dawley induced by DMBA 0.5% and divided into five treatment groups, namely positive control/C+ (sick), negative control/C- (healthy), and treatment group generated with DMBA and given extract C. cinerariifolium leaf with successive doses of T1, T2, and T3 (50, 100 and 200 mg/k g bw). The oral epithelium was stained with hematoxylin and eosin and immunohistochemically stained with a Ki-67 monoclonal antibody. Statistical analysis utilizing One-Way ANOVA.
Results:
The results showed that T1 at a dose of 200 mg/kg bw could significantly reduce Ki-67 expression and the degree of oral epithelial dysplasia (p

Key words: Carcinoma, C. cinerariifolium, Inflammation, Proliferation, DMBA






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