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Original Article

Open Vet J. 2023; 13(1): 99-107

Effect of ethanol extract from Chrysanthemum cinerariiforium leaves on Ki-67 proliferation and dysplasia severity in a rat model of oral squamous cell carcinoma

Anik Listiyana, Risma Aprinda Kristanti, Al Mazida Fauzil rumondang, Anggun Putri Maulana Ahmad, Lina Fitria Astari, Christyaji Indradmojo, Fidia Rizkiah Inayatilah.

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Oral Squamous Cell Carcinoma (OSCC) is a malignant tumor that can rapidly infiltrate the oral epithelial tissue and cause high mortality worldwide because the available therapies are less effective. Chrysanthemum cinerariifolium leaf contains secondary metabolites as anti-inflammatory, antioxidant, anticancer, and antimutagenic.
The study aimed to analyze the ethanolic extract of C. cinerariifolium leaf in reducing proliferation (Ki-67) and the degree of dysplasia in OSCC rats.
This study used male Sprague Dawley induced by DMBA 0.5% and divided into five treatment groups, namely positive control/C+ (sick), negative control/C- (healthy), and treatment group generated with DMBA and given extract C. cinerariifolium leaf with successive doses of T1, T2, and T3 (50, 100 and 200 mg/k g bw). The oral epithelium was stained with hematoxylin and eosin and immunohistochemically stained with a Ki-67 monoclonal antibody. Statistical analysis utilizing One-Way ANOVA.
The results showed that T1 at a dose of 200 mg/kg bw could significantly reduce Ki-67 expression and the degree of oral epithelial dysplasia (p

Key words: Carcinoma, C. cinerariifolium, Inflammation, Proliferation, DMBA

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