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Original Research

RMJ. 2011; 36(4): 313-315


Antithyroid effects of Diphenyl hydantoin Sodium

Rehana Rehman, Lubna Faroqi, Rakhshaan Khan.

Abstract
Objective
To confirm antithyroid effects of Diphenyl hydantoin (DPH) and determine whether they are reversible by the administration of putrescine in rats.
Methods
A randomized control trial was carried out during a period of four weeks on 30 female rats weighing 248 to 320 grams. They were divided into three groups each comprised of ten rats; Group I (control) was treated with normal saline, Group II (DPH treated) and Group III (treated with DPH and Putrescine). After the treatment, blood was collected by cardiac puncture on 18th day and radioimmunoassay was performed to measure Serum T3 (triiodo thyronine), T4 (Thyroxine) and TSH (Thyroid stimulating hormone) levels in all groups. Results were considered to be significant at p value

Key words: Diphenyl hydantoin, putrescine, T3, T4, TSH, hypothyroidism.


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