For the last two decades, oral drug delivery system was extensively discussed in the pharmaceutical field which includes
Orally Disintegrating Film (ODF) due to its advantages over other oral dosage form such as tablet and capsule. ODF can be taken
without water and classified as patient friendly dosage form especially for geriatric and pediatric who affected the most with
swallowing disorder. ODF manufactured by various methods such as solvent casting method, semi solid casting method, hot
melting extrusion, solid dispersion extrusion, rolling method and spraying method. ODF formulated using several chemicals like
hydrophilic polymers, plasticizer, saliva stimulating agent, surfactant, sweeteners, API, coloring, and flavoring agents. Validation
tests such as thickness test, folding endurance, tensile strength, young modulus, disintegration, and dissolution test performed to
analyze the mechanical properties, disintegration, and dissolution profile of the film. Some challenges will be encountered in the
process of formulating ODF such as API insolubility, unpleasant taste of API, stability issue, and dose uniformity. Those challenges
can be overcome with great formulations, high standard manufacturing methods and ideal storage management. In general, ODF
have great potential in pharmaceutical market and can be a good tool to enhance the therapeutic convenient of patient which then
lead to advancement of healthcare system.
Key words: oral, ODF, therapeutic convenient
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