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SRP. 2020; 11(10): 31-35

Dentin Matrix Protein-1 (DMP-1) Expression after Application of Haruan Fish Extract (Channa striata) on Inflamed Wistar Rat Dental Pulp

Andi Sumidarti, Christine Anastasia Rovani, Juni Jekti Nugroho, Bulkis Thahir.


Haruan fish (Channa striata) contains essential compounds such as albumin, amino acids, zinc (Zn), iron (Fe), and hydroxyapatite minerals that can play a role in the process of inflammation, proliferation and cell differentiation. Odontoblast cell activity can be analyzed through DMP-1 expression. The purpose of this study is to determine the effect of administration of extract of Haruan fish (Channa striata) on the interpretation of DMP-1 on inflamed rat dental pulp. This study was an experimental laboratory with a posttest only study design with a control group design. The research sample was nine groups of rats with 27 animals divided into 3, 7, and 14 days of observation, and occlusal preparation was performed on the first molar. Calcium hydroxide was given to the positive control group, extract of the Haruan fish in the treatment group, and the group negative control no application. Then the expression of DMP-1 was examined by immunohistochemical examination. Data were analyzed using Anova statistical test, Kruskal-Wallis, and chi-square test. The extract of the Haruan fish (Channa striata) can increase the expression of DMP-1 because the calcium and phosphate ion content in the Haruan fish extract can be a carrier of bioactive molecules and can increase the differentiation of odontoblast cells. The expression of DMP1 has increased after applying the extract of the Haruan fish (Channa striata) so that it can be considered a dent in biomineral material that can increase the proliferation and differentiation of odontoblast cells.

Key words: Haruan Fish, Immunohistochemistry, DMP1 Expression.

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