Lung cancer has been the most common diagnosed cancer for the last several decades. It is the leading cause of cancer mortality worldwide and has a dismal prognosis owing to discovery of it at a late stage. The pathogenesis of lung cancer entails a build-up of many molecular malformations over a lengthy time .In recent years, there is significant advances in the understanding of the molecular biology that promotes lung cancer, which has resulted in a revolution in the diagnosis and treatment of lung cancer depending on an individual's tumor genotype. In this review article, we will give a highlight on the breakthrough the clinically relevant genetic changes in lung cancer including oncogene activation, tumor suppressor gene inactivation and other subscribed aspects that has the potential to open up new treatment avenues.
Key words: lung cancer, molecular biology, biomarkers, mutations