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IJMDC. 2021; 5(1): 1-5

Vanillylacetone modulates acetaminophen induced hepatotoxicity in rats

Fadwa Fahad Alkhuraisi, Abdullah Mohammed Qahl, Sulaiman Abdulaziz Alderaibi, Abdulatif Arif Ibrahim Hadadi, Yasir Mohammed Hanbashi, Naif Ali Arishi, Nasser Ali Mansour Hanbashi.


Background: Acetaminophen (APAP) overdose is the most common type of drug-induced liver toxicity in humans. In this study, we investigated the protective mechanism of Vanillylacetone, which is the active ingredient of Ginger against APAP.
Methodology: Rats were classified into four groups, and each was having six rats. Group-I was controlling, and the vehicle was given orally. Group II was toxic, and APAP was administered 2 g/kg p.o for 7 days. Group III was treating Vanillylacetone 60 mg/kg body weight given every day p.o. for 7 days. Group IV was parse and only given Vanillylacetone (60 mg/kg body weight) for 7 days. On day 8, the blood was collected, and rats were sacrificed immediately.
Results: The levels of hepatic enzymes were monitored, and the result was significantly increased in Group-II (Toxic) as compared to Group-I (control). The level of these enzymes was decreased in Group-III (Toxic drug), and no changes in serum marker were observed in Group-IV compared to Group-I. The oxidative stress parameter like left posterior oblique (LPO) was also measured, and results indicated a significant increment in the content of thiobarbituric acid reactive substances (TBARS) in Group-II compared to Group-I. At the same time, the glutathione was reduced in Group-II as compared to Group-I. Still, after the treatment with Vanillylacetone, it was significantly recovered in Group-III as compared to Group-II. Thus, the outcome provides a clear picture of the protective mechanism of Vanillylacetone against APAP-induced hepatotoxicity.
Conclusion: This result showed that the Vanillylacetone effectively suppresses the harmful effect of APAP on the liver due to its antioxidant properties, which had a major role in preventing the induction of hepatotoxicity.

Key words: Acetaminophen, hepatotoxicity, rats, Vanillylacetone

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