Background: Isolated lipid derangements are no longer considered as an ideal tool to predict cardiovascular (CV) morbidity. Hence, novel parameters, that is, lipid ratios are being resorted to label CV risk. However, which of the ratios stand out as the most specific, sensitive, and earliest predictor in individual cases is still to be elucidated.
Aims and Objectives: The aim of the study was to study correlation of cholesterol ratios and conventional isolated lipid parameters as CV risk markers to anthropometric and hemodynamic variables in healthy overweight/obese subjects.
Materials and Methods: This was an analytical, observational, and pilot study enrolling 30 overweight/obese subjects as cases and 30 non-obese subjects as controls segregated on basis of body mass index (BMI) and WHR. All subjects with secondary cause of abnormal blood flow were excluded from the study. Blood pressure measurement and venous blood sampling for serum glucose and fasting lipid parameters were duly done.
Results: Of all the isolated lipid values and the three lipid ratios (Total Chl a [T. Chl]/high density lipoprotein [HDL], low-density lipoprotein [LDL]/HDL, triglyceride [TG]/HDL), the two groups differing significantly only in T. Chl/HDL ratio which, in turn, significantly strongly positively correlated to both LDL/HDL and TG/HDL ratio ([r = 0.684, P = 0.000] [r = 0.433, P = 0.001]), respectively. All the physical hemodynamic parameters (systolic blood pressure, diastolic blood pressure, and pulse pressure) were significantly different in both groups but none of them correlated with the lipid parameters. Of the two (waist hip ratio and BMI) anthropometric measures, only BMI had significant positive moderate strength correlation to lipid parameters and ratios.
Conclusion: T. Chl/HDL ratio seems to be the ideal lipid marker in early prediction of CV disease in apparently healthy obese subjects. Lipid derangements in apparently healthy mild-to-moderate grade obese subjects may not universally present with hemodynamic derangements.
Key words: Cholesterol Ratio; Lipid Profile; Cardiovascular Diseases; Pulse Pressure
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