Obesity is a dangerous health concern; and nowadays it becomes epidemic. It is a target factor for many diseases
including type 2 diabetes mellitus (T2DM). Adepokines are factors secreted from adipose tissue that affect many organs' function.
One of these adepokines is resistin. Resistin acts as a proinflammatory adepokine as it induces secretion of "tumor necrosis factor
alpha and interlukin-6" and mediates insulin resistance. In this study the level of fasting serum resistin, insulin, and C-reactive
protein (CRP) has been estimated, and the insulin resistance has been calculated by HOMA-IR for three groups: group one “thirty
obese patients who had T2DM”, group two “thirty obese healthy persons”, and group three “thirty healthy individuals with normal
body weight”. Serum resistin was higher in diabetic obese individuals than other two groups, and was positively correlated with
body mass index (BMI), insulin resistance, and CRP . In conclusion serum resistin links between the T2DM and inflammation.
Understanding the mechanism by which this link occurs, may help in clarification the role of resistin in the pathogenesis and
treatment of T2DM.
Key words: obesity, resistin, T2DM, inflammation, insulin resistance
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