Home|Journals|Articles by Year Follow on Twitter

Directory for Medical Articles

Open Access

Original Research

Non-Responsiveness To Hepatitis B Vaccination In Adolescents: Role Of HLA-DRB1 Alleles

Hartono Gunardi, Turyadi Turyadi, Susan Irawati Ie, David Handojo Muljono.

Background. Some healthy individuals do not respond to hepatitis B vaccination. The precise mechanism for non-responsiveness is unknown yet, although it has been associated with human leukocyte antigen (HLA), a host factor. This study investigated the association between HLA-DRB1 alleles and hepatitis B vaccine response in adolescents.
Methods. Senior high-school and college students aged 15-20 years old who had received primary hepatitis B vaccination during 0-5 year old with non-protective anti-HBs were recruited via stratified random sampling for Hepatitis B marker screening and booster administration. Anti-HBs was tested one month afterwards. All non-responders and randomly selected high responders were typed for HLA-DRB1. Non-responders were given additional booster doses and anti-HBs was evaluated one month afterwards.
Results. There were 213 students who had completed primary hepatitis B vaccination at 0-5 year age screened for Hepatitis B markers. Among these, 89 were negative for HBsAg, anti-HBc and anti-HBs, thus eligible for enrollment. However, only 84 gave their consent and participated in this study. Among 84 subjects, three did not respond to one dose of hepatitis B booster vaccine and were categorized as non-responders. The HLA-DRB1 alleles identified in non-responders were HLA-DRB1*0403, DRB1*1219, and DRB1*1301. Non-responsiveness to hepatitis B vaccine was not permanent, all non-responders seroconverted after administration of two or three doses of a booster vaccine.
Discussion. This study confirmed the association between certain HLA-DR alleles and lack of antibody response to hepatitis B vaccine.
Conclusions. The presence of certain HLA-DRB1 alleles in non-responders demonstrated that the HLA pattern influenced the immune response to hepatitis B vaccination. Administration of additional booster doses to non-responders could elicit protective immunity.

Key words: hepatitis B, vaccination, booster, adolescent, HLA, non-responsiveness

Similar Articles

Using the Health Belief Model to examine travelers' willingness to vaccinate and support for vaccination requirements prior to travel.
Suess C, Maddock J, Dogru T, Mody M, Lee S
Tourism management. 2022; 88(): 104405

A neuron's ambrosia: non-autonomous unfolded protein response of the endoplasmic reticulum promotes lifespan.
Homentcovschi S, Higuchi-Sanabria R
Neural regeneration research. 2022; 17(2): 309-310

The unintended consequences of the pandemic on non-pandemic research activities.
Walker J, Brewster C, Fontinha R, Haak-Saheem W, Benigni S, Lamperti F, Ribaudo D
Research policy. 2022; 51(1): 104369

Alternating in-source fragmentation with single-stage high-resolution mass spectrometry with high annotation confidence in non-targeted metabolomics.
Wasito H, Causon T, Hann S
Talanta. 2022; 236(): 122828

Ultrasensitive capacitance sensor to detect amyloid-beta 1-40 in human serum using supramolecular recognition of β-CD/RGO/ITO micro-disk electrode.
Le HTN, Kim D, Phan LMT, Cho S
Talanta. 2022; 237(): 122907

Full-text options

Latest Statistics about COVID-19
• pubstat.org

Add your Article(s) to Indexes
• citeindex.org

Covid-19 Trends and Statistics
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.

ScopeMed Web Sites