Abstract

Several eudistomin groups of compounds were identified from the organic extract of green ascidian Eudistoma viride using MALDI-TOF mass spectrometry. Apart from this we have discovered a series of unexplored mass traces belonging to different unidentified molecules with and without bromine moiety. The crude extract and its purified fractions were evaluated for the presence of anti- microbial activity against several human pathogenic bacteria. The results suggest that eudistomin-H and its non-brominated form eudistomin-I was potentially active against a panel of pathogenic bacteria.

Key words: ascidians, eudistomins, antimicrobial, mass spectrometry, brominated alkalloids