Obesity is a major complex disease caused by the interaction of a myriad of genetic, dietary, lifestyle, and environmental factors that lead to increased body fat mass. Over the years, it has grown to pandemic proportions affecting many children, adolescents and young adults exposed to this disorder for a longer period. Overactvity of aromatase cytochrome P450 enzyme which leads to increases of estrogen disrupting the hypothalamus pituitary axis, leptin secretion in testicular tissues, scrotal temperature, adipocytes environmental toxins /other toxic species and vascular endothelia dysfunction have been implicated in obesity. The use of natural products and their derivatives have historically been valuable as sources of therapeutic agents in the treatment of several metabolic disorders including obesity. In this review aims at looking the effect of natural products on obesity at pre-testicular, testicular and post-testicular levels of male reproductive system will be discussed.
Key words: Natural products, Obesity, Pre-testicular, Testicular, Post-testicular, Male reproductive system
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