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Physical and chemical properties of PVA-CMC based hydrogel carrier loaded with herbal hemostatic agent for application as wound dressings

Alisher Djumaev, Shokhista Tashmukhamedova.


Abstract

Background: Polyvinyl alcohol (PVA) -based hydrogels are promising biomaterials and suitable candidates for application as wound dressings due to their excellent biocompatibility and favorable properties.

Aims and Objectives: The present research focuses on the studying physical and chemical properties of PVA- chemistry manufacturing and controls (CMC) -based hydrogel carrier loaded with herbal hemostatic agent for application as wound dressings.

Materials and Methods: An aqueous solution of carboxymethyl cellulose was mixed in a certain ratio with PVA, to avoid the risks of chemical reagents and cross-linkers, for structure formation, the physical method of freezing-thawing cross-linking was used instead of using traditional chemical cross-linking.

Results: The physical and chemical properties of the obtained hydrogels, such as the gel fraction (GF), water uptake capacity, and protein adsorption, as well as viscoelastic properties, have been studied. The increased content of CMC reduced the GF, elasticity, and strength. However, this led to an increase in the degree of swelling and protein adsorption.

Conclusions: Hydrogels were developed using a physical method for application as wound dressings based on the PVA and CMC containing Inebrin derived from the medicinal plant Lagochílus inebrians as a model of topical hemostatic agent for capillary bleeding.

Key words: Hydrogel; Polyvinyl Alcohol; Sodium Carboxymethyl Cellulose; Inebrin; Freeze-thawing Method






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