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Original Article

ECB. 2022; 11(10): 30-40


A POWERFUL ANALYTICAL TECHNIQUE IN PHARMACEUTICAL DRUG DISCOVERY: RAPID RESOLUTION LIUID CHROMATOGRAPHY (RRLC)

Dr.G.Dharmamoorthy, M.S.Anupama, M. Sai Nandhini, K. Jhansi grace susmitha, S.Lakshmi Ramani, Dr.Anna Balaji.




Abstract

This review article should focus on the Rapid Resolution Liquid Chromatography (RRLC) has become an
increasingly useful approach to achieve higher throughput, improve sensitivity and reduce costs.The potential of high−speed
analyses by Rapid Resolution Liquid Chromatography (RRLC) on 1.8 μm porous particles packed into short columns
operated at high flow rate was investigated and compared to the performance of 5 μm porous par-ticles packed into
conventional colum. In order to display the practicality of RRLC separations, the isocratic analysis of pesticides and the
gradient analysis. Often higher temperatures are employed to minimize system back-pressure. With the widespread adoption
of RRLC comes the question of HPLC detector compatibility. The analysis time was reduced by a factor of 15, compared to the
conventional method

Key words: RRLC ,HPLC,Analysis






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