Background: The COVID-19 pandemic, as a catastrophic global event, has significantly changed the life of every human being with a negative impact on all health components: social, physical and mental. Pharmacotherapy did not provide the expected results, as well as WHO recommendations with measures of isolation, wearing masks and maintaining physical distance. Vaccination has not yet led to collective immunity, so every aspect of human health is still endangered. Objective: To point out the problem of COVID-19 pandemic is still important to analize according so many variants of virus mutation form and consequences within population besides almost 50 percent of population in every country has been vaccinated. Methods: Authors used dsriptive method of of valuation all variants of corona virus in the world untill now, and also evaluated eficassy and efficient of used treatments in the past, including efficasy of vaccination in prevention of COVID-19 infection. Results: Experiences of the Medicus A project in addressing COVID-19 infection and has an educational and practical model aspect which is ready for the prevention, early detection and treatment of COVID-19 patients. In the Medicus A model, priority is given to educating patients using ICT technologies, namely: telemedicine, online communication with patients, intensive communication with relatives and all necessary consultants in the health system. Conclusion: The Predictions of how the pandemic would unfold, were wrong on several occasions. Predictions of the current winter wave, in which Omicron dominates are somewhat more likely. Researchers at Columbia University have a model that predicts the peak of new cases in USA beginning on January 9, 2022, with about 2.5 million confirmed infections in that seven-day period - and potentially as many as 5 million infected people.
Key words: COVID-19 pandemic, SARS-CoV-2 virus mutations, vaccination. Medicus A.
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