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Review Article

SRP. 2020; 11(6): 794-802

Formulation, Development and Evaluation of Nanostructured Lipid Carrier (NLC) Based Gel for Topical Delivery of Diacerein.

Ganesh R. Pawbake, Satish V. Shirolkar.

Diacerein Nanostructured Lipid Carrier (NLC) topical gel was formulated to treat inflammation and the conditions associated with acceleration and prolonged action. Dispersion of nanoparticles was correctly gelled and characterized in pharmacology, pH, proliferation, rheology and in-vitro releases. NLC-based gel safety was assessed with primary skin irritation studies, and pharmacodynamics research confirmed efficacy. Non-steroidal anti-inflammatory drugs (NSAIDs), while known as extreme gastrointestinal and vascular adverse effects without resolving the underlying systemic cartilage injury, are the most widely used agents of osteoarthritis (OA) pain management. Many doctors are elderly. Thus, Diacerein is the preferred drug for strong analgesic benefit in serious OA discomfort. Diacerein is cost-effectiveand dose-efficient. Gel formulation offers easy application in all quantities at a pain site. The NLC-based gel demonstrated quicker start and extended habits up to 24 hours.

Key words: Diacerein, Nanostructured lipid carriers (NLC), Topical, Anti-inflammatory, Prolonged action.

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