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Review Article

SRP. 2020; 11(6): 780-784


The Correlation between Fibroblast Growth Factor 23 (FGF23) and Iron Profile in Chronic Kidney Disease Patients on Dialysis with Anemia

Mohammad Rudiansyah, Leonardo Lubis, Ria Bandiara, Bernadet Maria Sanjaya, Hendra Wana Nur’amin, Huldani, Abdul Hadi Martakusumah, Harun Achmad, Rully Marsis Amirullah Roesli, Dedi Rachmadi.

Abstract
Patients with chronic kidney disease on dialysis (CKD-5D) often develop various complications, one of them is iron deficiency anemia. Iron is needed as a raw material for the formation of red blood cells. Iron deficiency increases levels of Fibroblast Growth Factor 23 (FGF23). In CKD-5D patients, the functional iron deficiency often occurs and FGF23 levels increase. FGF23 levels can be a poor prognosis in CKD-5D. This study aims to find out the correlation between FGF23 with hemoglobin level, serum iron, total iron-binding capacity, and ferritin level in CKD-5D patients with anemia. This study was cross-sectional. Subjects were CKD patients undergoing routine hemodialysis (HD) twice a week at least 3 months, aged >18 years, anemia (hemoglobin levels

Key words: CKD-5D, Anemia, Iron deficiency, Hemoglobin, FGF23


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