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Review Article

SRP. 2020; 11(6): 656-660


Assessing the Fat Mass and Obesity Associated Gene Polymorphisms (rs17817449 and rs1588413) in Obesity and Type 2 Diabetes Mellitus

Abdulhussein A. Algenabi, Majid K. Hussein, Najah R. Hadi, Fadhil A. Nasser, Ghizal Fatima, Hayder A. Al-Aubaidy.


Abstract

This study aims to evaluate the effects of FTO gene polymorphism (rs17817449andrs1588413) as predictor/ risk factors of type 2 diabetes mellitus in obese Iraqi population. Four hundred obese participants clinically diagnosed with type 2 diabetes were enrolled in this study. A similar matching group of obese non-diabetic control group was also included in this study. Multi-nominal logistic regression analysis applied to study genotype and allele frequencies for FTO gene polymorphism (rs17817449, rs1588413) in patients and control groups. The homozygous genotype significantly (OR= 4.61, CI 95% 2.61-8.12, P

Key words: FTO gene polymorphisms; rs17817449; rs1588413; Type 2 diabetes; obesity






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