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SRP. 2020; 11(3): 712-717

Combined Enzyme Therapy in Patients with Complications after Lip Contour Correction in Cosmetology

Irina Pavlovna Aksenenko, Marina Yurievna Gerasimenko, Boris Aleksandrovich Polyaev, Viktoriya Valerievna Polunina, Inna Sergeevna Evstigneeva.


The study was aimed to evaluate the effectiveness of a combined method of treatment that includes a course of laser phoresis of Longidaza and diadynamophoresis of collalysin 1000 collagenase units for the correction of complications after lips contour correction with hyaluronic fillers. Materials and Methods. The study included 31 women aged 25 to 32 years old with complications developed after the injection of stabilized hyaluronic acid-based filler in the lip area. The patients were divided into three groups that received a course of laser phoresis of Longidaza, diadynamophoresis of collalysin or their combination. Results. A combined course of laser phoresis of Longidaza and diadynamophoresis of collalysin exerts significant clinical effect, reduces edema and gel conturation, and stabilizes psychoemotional status. Besides, this therapeutic complex accelerates biodegradation of filler, promotes restructuring effect on lip tissue, and provides expressed effect of a decrease in the thickness of the dermis and increase in the coefficient of dermis density, which is likely to be associated with a reduction of intradermal edema that develops as a reaction to the superficially injected filler. Conclusion. A combined course of laserphoresis of Longidaza and diadynamophoresis of collalysin in the lip area in patients with such complications as superficial filler injection or injection of an excessive amount of a drug based on stabilized hyaluronic acid is a highly effective method of treatment, which is confirmed by the resolution of clinical symptoms and the improvement of patientsÂ’ quality of life.

Key words: filler, stabilized hyaluronic acid, neuropathy, diadynamophoresis of collalysin, collagenase, hyaluronidase, complication after lip contour correction, laser phoresis of Longidaza

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