This research includes estimation of the Ciprofloxacin Hydrochloride drug using manufactured liquid selective membranes electrodes , where the selective electrodes of drug were prepared from the Active ingredient with Sodium tetra phenyl borate and using organic plasticizer (Di-n-butyl phthalate, DBPH) with (poly vinyl chloride, PVC) as a substrate. The results indicated that the tendency of the electrode CIP-STPB is 29.4 mV / decade at a range of the PH (2.5-4.0) and the electrode response was good for the concentrations of the pharmaceutical drug and the concentration was 10-1-10-4 molar, correlation coefficient 0.994, detection limit 2.5 x 10-8 µg.ml-1 and the electrode life time was fourteen days, and the electrode selectivity was measured with mono- and Dual-compounds and ions, and the electrode proved successful by estimating the drug with a regenerative not less than 98%.
Key words: ciprofloxacin hydrochloride, membrane selective electrodes CIP-STPB-DBPH
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