Objectives: This study aims to investigate the predictive role of the signal peptide-CUB-EGF domain-containing protein-1 (SCUBE-1)
in the presence of endothelial dysfunction.
Patients and methods: Between December 2014 and August 2015, 120 healthy young adults (68 males, 52 females; mean age 29.7±4.1 years;
range, 20 to 35 years) without a previous history of cardiovascular disease were included. The participants were divided into two groups
according to normal (n=73) and abnormal flow-mediated dilatation (FMD) response (n=47). Simultaneously, the standard biochemical
markers, blood urea-nitrogen, creatinine, liver enzymes, glucose, lipids and SCUBE-1 levels were determined from the blood samples.
Results: Multivariable logistic regression revealed a strong association between SCUBE-1 and FMD (p136.37 ng/mL, SCUBE-1 had 85.0% sensitivity and 81.2% specificity to identify abnormal FMD.
Conclusion: Our study findings indicate that there is a favorable inverse correlation between the SCUBE-1 and FMD.
Key words: Atherosclerosis progression; endothelial dysfunction; flow-mediated vasodilatation; SCUBE-1.
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