Home|Journals|Articles by Year Follow on Twitter

Directory for Medical Articles

Open Access

Research Article

EJMCM. 2014; 2(1): 16-19

Small molecule PAI-1 functional inhibitor attenuates vascular smooth muscle cell migration and survival: Implications for the therapy of vascular disease

Tessa M. Simone, Paul J. Higgins.

Focal points


Targeted pharmacologic disruption of PAI-1 function with small molecule inhibitors may have general applicability for the treatment of fibroproliferative disorders, in general, and vascular disease, in particular. The development orally compatible drugs would likely simplify delivery and patient compliance.


It is apparent that PAI-1 is a multi-functional SERPIN, affecting such diverse physiological and pathophysiological processes as smooth muscle cell growth, migration, survival and pericellular proteolysis activity. Clearly, PAI-1 functional blockade has widespread clinical implications that are not restricted to one aspect of the tissue response to injury.


The original small molecule panel of PAI-1 inhibitors derived from a collaboration between basic scientists and, largely, cardiovascular disease-oriented medical chemists as well as pharmaceutical investigators. This collegial relationship is expected to expand as it is evident that PAI-1 inhibition has generally utility in the treatment of cardiovascular diseases, tissue fibrosis (in particular, the renal and pulmonary systems) and cancer.

Key words: Vascular diseasePAI-1SERPINPericellular proteolysisTiplaxtininVascular smooth muscle cellsMigrationApoptosis

Similar Articles

Plasma osteopontin as a biomarker of Alzheimer's disease and vascular cognitive impairment.
Chai YL, Chong JR, Raquib AR, Xu X, Hilal S, Venketasubramanian N, Tan BY, Kumar AP, Sethi G, Chen CP, Lai MKP
Scientific reports. 2021; 11(1): 4010

Utility of computed tomography angiography in traumatic lower limb injury: Review of clinical impact in level 1 trauma centre.
Joseph TI, Ratnakanthan PJ, Paul E, Clements W
Injury. 2021; ():

Nerve transfer for restoration of lower motor neuron-lesioned bladder function. Part 2: Attenuation of purinergic bladder smooth muscle contractions.
Frara N, Giaddui D, Braverman AS, Porreca DS, Brown JM, Mazzei M, Wagner IJ, Pontari MA, Tiwari E, Testa CL, Yu D, Hobson LJ, Barbe MF, Ruggieri MR
American journal of physiology. Regulatory, integrative and comparative physiology. 2021; ():

Mechanical Circulatory Support Devices: Management and Prevention of Vascular Complications.
Sohal S, Tayal R
Interventional cardiology clinics. 2021; 10(2): 269-279

Nerve transfer for restoration of lower motor neuron-lesioned bladder function. Part 3: Correlation between histological changes and nerve evoked contractions.
Barbe MF, Testa CL, Cruz GE, Frara N, Tiwari E, Hobson LJ, McIntyre BS, Porreca DS, Giaddui D, Braverman AS, Day EP, Amin M, Brown JM, Mazzei M, Pontari M, Wagner IJ, Ruggieri MR
American journal of physiology. Regulatory, integrative and comparative physiology. 2021; ():

Effects of the herbal preparation STW 5-II on in vitro muscle activity in the guinea pig stomach.
Schemann M, Landmann M, Kelber O, Ammar RM, Krueger D, Michel K
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility. 2021; 33(2): e13984

Melatonin role in skeletal muscle disorders.
Salucci S, Taurone S, Burattini S, Gobbi P, Clausi J, Battistelli M
European review for medical and pharmacological sciences. 2021; 25(2): 1024-1033

A highly-sensitive vascular endothelial growth factor-A(165) immunosensor, as a tool for early detection of cancer.
Taati Yengejeh F, Shabani Shayeh J, Rahmandoust M, Fatemi F, Arjmand S
Journal of biomedical materials research. Part B, Applied biomaterials. 2021; ():

Full-text options

American Journal of Diagnostic Imaging


Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.