Monomers contain pyrrole and thiophene moieties and conjugated Schiff basses were synthesized. The study herein
describes the electrochemical detection of some drugs, specifically paracetamol and metronidazole. Modification of electrodes with
functional groups such as Schiff bases leads to improves sensitivity of the electrode to analytes. In this study, a glassy carbon
electrode has, for the first time, been modified with poly(schiff bases) in acetonitrile containing tetrabutylammonium perchlorate
(TBAP) to detect paracetamol and metronidazole. The structures of prepared compounds were characterized by Fourier transform
infrared spectroscopy, Proton and Carbon-13 Nuclear Magnetic Resonance and Electron Ionization Mass Spectroscopy. The
electrochemical synthesis and redox state response in monomer-free electrolytes synthesized films have examined by using cyclic
voltammetry. A voltammetric sensor based on a polymeric schiff bases film coated GC electrode was developed. The proposed
electrode was appropriate for detection of paracetamol and metronidazole in pharmaceutical formulations.
Key words: Schiff base, electroactive polymer, modified electrode, electrochemical sensors and cyclic voltammetry
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