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Research Article

EJMCM. 2016; 3(1): 22-29

Development and characterization of chitosan-based antimicrobial films incorporated with streptomycin loaded starch nanoparticles

Neethu Hari, Ananthakrishnan Jayakumaran Nair.

Nowadays, Chitosan has attained more attention due to its potential applications in food, agriculture and
pharmaceutics. The cationic nature of chitosan enhances the film forming capacity of this polymer.
However, films made only from chitosan lack water resistance and have reduced mechanical properties.
The functional properties of chitosan films can be improved when chitosan films are combined with
other film forming materials. The objective of this study was to prepare chitosan based antimicrobial
films by the incorporation of streptomycin loaded starch Nanocrystals. Different properties of this film
such as swelling nature, moisture content, degradation nature and the antimicrobial activity of modified
chitosan films were investigated. Drug releasing efficacy of the film was also studied. The addition of
streptomycin loaded Starch nanocrystals in chitosan-gelatin film increased crystallinity of the film,
lowered the swelling nature of the film to a controlled manner. Moreover the Modified chitosan based
antimicrobial film showed almost 90% of Escherichia coli inhibition and 80% of Bacillus subtilis inhibition
and also the film showed a sustained release (60%) of streptomycin for 10 days.
Focal point:
Synthesis of streptomycin loaded starch nanoparticles (SS-NPs) using nanoprecipitation method and
the development of novel chitosan based antimicrobial film by the incorporation of streptomycin
loaded starch nanoparticles using solvent casting technique
Development of potential multifunctional antimicrobial film for medical, pharmaceutical and food
based applications due to its excellent film forming ability, biocompatibility, biodegradability and
antimicrobial property
The designed unique antimicrobial film, if finely tuned, can be used both in biomedical fields for
developing scaffolds in tissue engineering, wound dressing material, capsule material for sustained
drug release and immobilization of enzyme and food industry as packaging material
Financial investment and support from government would help to develop new novel translational
tools which contribute for better health care and also help to reduces disease burden
Stringent regulatory principles limit the clinical trials essential for validation of biomaterials which
might have turned in to a highly beneficial multifunctional product such as antimicrobial film potentially
useful both in biomedical and food industry

Key words: Antimicrobial filmsChitosanGelatinStarch nanoparticlesStreptomycin

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