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Research Article

EJMCM. 2017; 4(1): 23-30


Synthesis of a series of new 6-nitrobenzofuran-2-carbohydrazide derivatives with cytotoxic and antioxidant activity

Muhammad Taha, Sadia Sultan, Mohamad Azlan, Syed Adnan Ali Shah, Waqas Jamil,Swee Keong Yeap, Syahrul Imranb, Muhammad Nadeem Akhtar, Seema Zareenf,Nor Hadiani Ismailb, Muhammad Alih.

Abstract
6-nitrobenzofuran-2-carbohydrazide Schiff base derivatives have been synthesized and their structure has been confirmed via H1NMR, Mass spectrometry and elemental (CHN/S) analysis. These synthesized analogs showed significant cytotoxic and antioxidant activity. Doxorubicin (IC50 = 0.94 0.20 μM) and n-propyl gallate (IC50 = 30.30 0.40 μM) were used as standard in cytotoxic and antioxidant activities, respectively. Compound 1 (IC50 = 3.30 0.90 μM), 2 (IC50 = 2.70 0.25 μM), 3 (IC50 = 2.70 0.25 μM), 10 (IC50 = 2.70 1.10 μM), 11 (IC50 = 1.00 1.20 μM), and 17 (IC50 = 3.75 0.90 μM) showed excellent while 21 (IC50 = 7.50 0.60 μM) and 28 (IC50 = 7.50 0.66 μM) showed moderate anti cancer activity. Furthermore, compound 10 (IC50 = 17.50 0.85 μM), 11 (IC50 = 24.20 0.55 μM), 12 (IC50 = 21.10 1.58 μM), 13 (IC50 = 14.60 0.32 μM), 14 (IC50 = 29.20 0.75 μM) and 15 (IC50 = 9.26 0.15 μM) showed better antioxidant activity than the standard n-propyl gallate. This study will be useful to develop potential lead molecules with cytotoxic and antioxidant potential.

Key words: 6-nitrobenzofuran-2-carbohydrazideCytotoxicityCytotoxic antioxidant



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