Home|Journals|Articles by Year Follow on Twitter

Directory for Medical Articles

Open Access

Research Article

EJMCM. 2017; 4(1): 23-30

Synthesis of a series of new 6-nitrobenzofuran-2-carbohydrazide derivatives with cytotoxic and antioxidant activity

Muhammad Taha, Sadia Sultan, Mohamad Azlan, Syed Adnan Ali Shah, Waqas Jamil,Swee Keong Yeap, Syahrul Imranb, Muhammad Nadeem Akhtar, Seema Zareenf,Nor Hadiani Ismailb, Muhammad Alih.

6-nitrobenzofuran-2-carbohydrazide Schiff base derivatives have been synthesized and their structure has been confirmed via H1NMR, Mass spectrometry and elemental (CHN/S) analysis. These synthesized analogs showed significant cytotoxic and antioxidant activity. Doxorubicin (IC50 = 0.94 0.20 μM) and n-propyl gallate (IC50 = 30.30 0.40 μM) were used as standard in cytotoxic and antioxidant activities, respectively. Compound 1 (IC50 = 3.30 0.90 μM), 2 (IC50 = 2.70 0.25 μM), 3 (IC50 = 2.70 0.25 μM), 10 (IC50 = 2.70 1.10 μM), 11 (IC50 = 1.00 1.20 μM), and 17 (IC50 = 3.75 0.90 μM) showed excellent while 21 (IC50 = 7.50 0.60 μM) and 28 (IC50 = 7.50 0.66 μM) showed moderate anti cancer activity. Furthermore, compound 10 (IC50 = 17.50 0.85 μM), 11 (IC50 = 24.20 0.55 μM), 12 (IC50 = 21.10 1.58 μM), 13 (IC50 = 14.60 0.32 μM), 14 (IC50 = 29.20 0.75 μM) and 15 (IC50 = 9.26 0.15 μM) showed better antioxidant activity than the standard n-propyl gallate. This study will be useful to develop potential lead molecules with cytotoxic and antioxidant potential.

Key words: 6-nitrobenzofuran-2-carbohydrazideCytotoxicityCytotoxic antioxidant

Similar Articles

Study on the antioxidative mechanism of tocopherol loaded ethyl cellulose particles in thermal-oxidized soybean oil.
Liu Y, Ma X, Li J, Fan L, Huang S
Carbohydrate polymers. 2022; 276(): 118734

Antioxidant activity, stability, in vitro digestion and cytotoxicity of two dietary polyphenols co-loaded by β-lactoglobulin.
Ren Y, Liu H, Wang D, Liu T, Zhang R, Wu Y, Zhang Y, Han J, Liu M
Food chemistry. 2022; 371(): 131385

Mussel-inspired adhesive antioxidant antibacterial hemostatic composite hydrogel wound dressing via photo-polymerization for infected skin wound healing.
Yang Y, Liang Y, Chen J, Duan X, Guo B
Bioactive materials. 2022; 8(): 341-354

Multi-generational effects of enrofloxacin on lifespan and reproduction of Caenorhabditis elegans with SKN-1-mediated antioxidant responses and lipid metabolism disturbances.
Zheng Y, Yu Z, Zhang J
The Science of the total environment. 2022; 804(): 150250

Reactive oxygen species-based nanomaterials for the treatment of myocardial ischemia reperfusion injuries.
Zhao T, Wu W, Sui L, Huang Q, Nan Y, Liu J, Ai K
Bioactive materials. 2022; 7(): 47-72

Full-text options

Latest Statistics about COVID-19
• pubstat.org

Add your Article(s) to Indexes
• citeindex.org

Covid-19 Trends and Statistics
Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.

ScopeMed Web Sites