Home|Journals|Articles by Year Follow on Twitter

Directory for Medical Articles

Open Access

Research Article

EJMCM. 2017; 4(1): 23-30

Synthesis of a series of new 6-nitrobenzofuran-2-carbohydrazide derivatives with cytotoxic and antioxidant activity

Muhammad Taha, Sadia Sultan, Mohamad Azlan, Syed Adnan Ali Shah, Waqas Jamil,Swee Keong Yeap, Syahrul Imranb, Muhammad Nadeem Akhtar, Seema Zareenf,Nor Hadiani Ismailb, Muhammad Alih.

6-nitrobenzofuran-2-carbohydrazide Schiff base derivatives have been synthesized and their structure has been confirmed via H1NMR, Mass spectrometry and elemental (CHN/S) analysis. These synthesized analogs showed significant cytotoxic and antioxidant activity. Doxorubicin (IC50 = 0.94 0.20 μM) and n-propyl gallate (IC50 = 30.30 0.40 μM) were used as standard in cytotoxic and antioxidant activities, respectively. Compound 1 (IC50 = 3.30 0.90 μM), 2 (IC50 = 2.70 0.25 μM), 3 (IC50 = 2.70 0.25 μM), 10 (IC50 = 2.70 1.10 μM), 11 (IC50 = 1.00 1.20 μM), and 17 (IC50 = 3.75 0.90 μM) showed excellent while 21 (IC50 = 7.50 0.60 μM) and 28 (IC50 = 7.50 0.66 μM) showed moderate anti cancer activity. Furthermore, compound 10 (IC50 = 17.50 0.85 μM), 11 (IC50 = 24.20 0.55 μM), 12 (IC50 = 21.10 1.58 μM), 13 (IC50 = 14.60 0.32 μM), 14 (IC50 = 29.20 0.75 μM) and 15 (IC50 = 9.26 0.15 μM) showed better antioxidant activity than the standard n-propyl gallate. This study will be useful to develop potential lead molecules with cytotoxic and antioxidant potential.

Key words: 6-nitrobenzofuran-2-carbohydrazideCytotoxicityCytotoxic antioxidant

Similar Articles

Effects of hydrogen water treatment on antioxidant system of litchi fruit during the pericarp browning.
Yun Z, Gao H, Chen X, Chen Z, Zhang Z, Li T, Qu H, Jiang Y
Food chemistry. 2021; 336(): 127618

Antioxidant films and coatings based on starch and phenolics from Spondias purpurea L.
Rodrigues FAM, Dos Santos SBF, de Almeida Lopes MM, Guimarães DJS, de Oliveira Silva E, de Sá Moreira de Souza Filho M, Mattos ALA, da Silva LMR, de Azeredo HMC, Ricardo NMPS
International journal of biological macromolecules. 2021; ():

Conversion of Wheat Bran to Xylanases and Dye Adsorbent by .
Tran TN, Doan CT, Wang SL
Polymers. 2021; 13(2):

Effect of drought on photosynthesis, total antioxidant capacity, bioactive component accumulation, and the transcriptome of Atractylodes lancea.
Zhang A, Liu M, Gu W, Chen Z, Gu Y, Pei L, Tian R
BMC plant biology. 2021; 21(1): 293

Effect of Physiological Concentrations of Vitamin C on the Inhibitation of Hydroxyl Radical Induced Light Emission from Fe-EGTA-HO and Fe-EGTA-HO Systems In Vitro.
Nowak M, Tryniszewski W, Sarniak A, Wlodarczyk A, Nowak PJ, Nowak D
Molecules (Basel, Switzerland). 2021; 26(7):

Full-text options

Add your Article(s) to Indexes
• citeindex.org

Follow ScopeMed on Twitter
Author Tools
eJPort Journal Hosting
About BiblioMed
License Information
Terms & Conditions
Privacy Policy
Contact Us

The articles in Bibliomed are open access articles licensed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
ScopeMed is a Database Service for Scientific Publications. Copyright ScopeMed Information Services.